(Download) "Immunoradiometric Assay of Circulating C-Reactive Protein: Age-Related Values in the Adult General Population (Enzymes and Protein Markers)" by Clinical Chemistry ~ Book PDF Kindle ePub Free

eBook details
- Title: Immunoradiometric Assay of Circulating C-Reactive Protein: Age-Related Values in the Adult General Population (Enzymes and Protein Markers)
- Author : Clinical Chemistry
- Release Date : January 01, 2000
- Genre: Chemistry,Books,Science & Nature,
- Pages : * pages
- Size : 211 KB
Description
Measurement of C-reactive protein (CRP), [5] the classical acute phase protein, is an extremely valuable marker of disease activity and response to therapy in a wide range of tissue-damaging, inflammatory, infective, and neoplastic conditions (1). The original automated nephelometric and turbidimetric immunoassays for CRP developed in the 1970s and the homogeneous enzyme and fluorescence polarization methods introduced in the early 1980s had limited sensitivity and poor precision in the low range. Thus, values below 5-10 mg/L could not be detected, although later improvements in some systems reduced the limit of detection to ~2 mg/L. This was not a problem because the median value for serum CRP in apparently healthy adults is ~0.8 mg/L, the 90th centile of the distribution in such subjects is ~3 mg/L, and all the information required for the classical applications of clinical CRP measurement in adults derives from increases in CRP concentration above these concentrations (1, 2). However, the recent use of more sensitive immunoassays for CRP has revealed exciting new information of both fundamental and clinical importance in three different areas: coronary heart disease and other complications of atherosclerosis (3-15), osteoarthritis (16), and neonatal infections (17). Although there now are several commercially available, routine clinical chemistry assays capable of precisely measuring circulating CRP concentrations within what was previously considered to be the reference interval, these were not available when we commenced our studies (3, 6). We therefore developed, and report here, a sensitive solid-phase monoclonal-polyclonal IRMA designed to measure CRP in plasma or serum of all subjects in the general population (12,18-21).
Free PDF Download "Immunoradiometric Assay of Circulating C-Reactive Protein: Age-Related Values in the Adult General Population (Enzymes and Protein Markers)" Online ePub Kindle
- [Download] "Impact of CK-MB Testing Policies on Hospital Length of Stay and Laboratory Costs for Patients with Myocardial Infarction Or Chest Pain (Test Utilization and Outcomes)" by Clinical Chemistry ~ eBook PDF Kindle ePub Free
- (Download) "Immunochemistry of Lysosomal Storage Disorders (Clinical Report)" by Clinical Chemistry # Book PDF Kindle ePub Free
- [Download] "Impact of the Third Cholesterol Report from the Adult Treatment Panel of the National Cholesterol Education Program on the Clinical Laboratory (Special Report)" by Clinical Chemistry # Book PDF Kindle ePub Free